Annabel Lee as a Representative of Poe’s Poems free essay sample

Annabel Lee as an agent of Poe’s sonnets about death of delightful ladies Its consistently somewhat difficult to isolate the life of the incredible Poe from his works. For this situation, there are some striking similitudes. „Annabel Leeâ€Å" is the last total sonnet composed by Poe, distributed not long after his passing in 1849. In the same way as other of Poes sonnets including The Raven, Ulalume, and To One in Paradiseâ€Å", it investigates the topic of the demise of a delightful lady, â€Å"the most poetical theme on the planet, as indicated by Poe. Specifically, despite the fact that the sonnets refrains have a to some degree unpredictable length and structure, the rhyme conspire consistently stresses the three words me, Lee, and ocean, authorizing the connected idea of these ideas inside the sonnet while giving the sonnet a melody like sound. The work shows Poes visit obsession with the Romantic picture of a lovely lady who has passed on too youthful out of the blue. As showed all the more altogether in his short story The Oval Portrait, Poe frequently connected demise with the freezing and catching of excellence, and a significant number of his courageous women arrive at the zenith of exquisiteness on their deathbed. The storyteller, who began to look all starry eyed at Annabel Lee when they were youthful, holds his adoration for her considerably after her demise. The vast majority concur that Edgar Allan Poe composed Annabel Lee about his left spouse, Virginia, who passed on of tuberculosis two years sooner. A few pundits, be that as it may, battle that in the seventh line of the sonnet he states, I was a youngster and she was a kid, and he unquestionably was no kid in 1836 at twenty-seven when he wedded his thirteen-year-old lady of the hour. Possibly the sonnet is about a prior affection, or maybe it is absolutely anecdotal, yet tending to Annabel Lee as his life and his lady of the hour in line thirty-eight and composing it two years after his darling youthful wifes demise, it appears to be just coherent that it is to be sure expounded on her and is essentially weaved with a touch of lovely permit. Neighborhood legend in Charleston, South Carolina recounts to the narrative of a mariner who me t a lady named Annabel Lee. Her dad opposed the matching and the two met secretly in a burial ground before the mariners time positioned in Charleston was up. While away, he knew about Annabels demise from yellow fever, however her dad would not permit him at the memorial service. Since he didn't have any acquaintance with her accurate internment area, he rather kept vigil in the burial ground where they had frequently furtively met. There is no proof that Edgar Allan Poe had known about this legend, however some demand it was his motivation. The sonnet centers around a perfect love which is bizarrely solid. Truth be told, the storytellers activities show that he adores Annabel Lee, however he reveres her, something he can just do after her passing. The sonnet explicitly makes reference to the young people of the anonymous storyteller and particularly of Annabel Lee, and it commends youngster like feelings in a manner steady with the standards of the Romantic time. Numerous Romantics from the eighteenth and nineteenth hundreds of years saw adulthood as a defilement of the cleaner senses of adolescence, and they favored nature to society since they believed it to be a superior and increasingly intuitive state. Appropriately, Poe treats the storytellers youth love for Annabel Lee as more full and more interminable than the affection for grown-ups. Annabel Lee is delicate and steady in her affection, and she has no perplexing feelings. He clarifies that heavenly attendants killed her. His reiteration of this declaration proposes he is attempting to justify his own unreasonable sentiments of misfortune. In Annabel Lee the speaker contends in lines eleven and twelve that the blessed messengers were desirous of the upbeat couple: the winged seraphs of paradise pined for her and me. The jealous blessed messengers, he demands, made the breeze cool his lady of the hour and hold onto her life. In any case, he battles, their adoration, more grounded than the affection for the more established or more shrewd couples, can never be vanquished: And neither the edges in paradise above, Nor the devils down under the ocean, Can ever dissever my spirit from the spirit Of the lovely Annabel Lee. (lines 33-36) In contrast to The Raven, in which the storyteller accepts he will nevermore be brought together with his adoration, Annabel Lee says the two will be together again, as not even devils can ever dissever their spirits. The first occasion when that demise gets referenced in the sonnet: A breeze extinguished of a cloud, cooling My wonderful Annabel Lee; (lines 15-16) The speaker doesnt state she kicked the bucket. As a matter of fact, he never utilizes the word demise in this sonnet by any means. The speaker keeps up that this universe of dream stays considerably after the passing of his lady of the hour: For the moon never pillars without bringing me dreams Of the lovely Annabel Lee; And the stars never rise yet I feel according to the delightful Annabel Lee (33-6). The sonnets setting has a few Gothic components, as the realm by the ocean is forlorn and in a vague however secretive area. Poe doesn't portray the setting with any explicitness, and he weaves a foggy, sentimental environment around the realm until he finishes by offering the extreme and awful picture of a tomb there by the ocean. Simultaneously, the nostalgic tone and the Gothic foundation serve to rehash the picture of an adoration that outlives all pposition, from the otherworldly envy of the holy messengers to the physical hindrance of death. In spite of the fact that Annabel Lee has passed on, the storyteller can in any case observe her splendid eyes, a picture of her spirit and of the flash of life that gives a guarantee of a future gathering between the two sweethearts. The picture summoned by this sonnet is of suffering adoration. Both this everlasting affection and the finish of the sonnet leave the speaker lying on the grave of his withdrew spouse: And in this way, all the night-tide, I rests by the side Of my dear my sweetheart my life and my lady of the hour, In the tomb there by the ocean, In her burial place by the sounding ocean (37-41). As on account of various Poes male heroes who grieve the unexpected passing of cherished ladies, the affection for storyteller of Annabel Lee goes past straightforward reverence to an increasingly unusual connection. While Annabel Lee appears to have cherished him in a basic, if nonsexual, way, the hero has intellectually consecrated her. He accuses everybody except himself for her demise, pointing at the intrigue of blessed messengers with nature and at the demonstration of paternalism characteristic in her aristocratic family who came and bore her away, and he stays subordinate upon her memory. While the storyteller of the sonnet Ulalume experiences an oblivious need to lament and to come back to Ulalumes grave, the storyteller of Annabel Lee picks unexpectedly to rests and rest close to a lady who is herself resting by the ocean. Refferences: A History of American Literature: Then and Now, Radojka Vukcevic, Podgorica, 2005 The Cambridge Companion to Edgar Allan Poe, altered by Kevin J. Hayes. Cambridge University Press, 2002

How to Add WordPress Push Notifications to Your Site (3 Easy Steps)

Getting the enthusiasm of your guests is an extreme undertaking, yet not even close as troublesome as saving them ready as long as possible. One of the more current approaches to prevail with regards to doing soâ is to make sense of the most ideal approaches to reach usersâ outside your websiteâ †consequently the need to consider including WordPress push notifications.WordPress message pop-ups empower you to set up an immediate line of correspondence withâ your crowd. Theyre unmistakably more clear than messages and are more captivating than customary battles. On the off chance that you learnâ how to convey them, they can turn into a tremendous shelter to your site.In this article, well clarify why WordPress message pop-ups are so valuable. At that point, well guide you through the way toward setting them up on your site utilizing the free OneSignal module. Lets get cracking!What pop-up messages are (and why you should utilize them)WordPress pop-up messages are easy to comp rehend and set up. In the event that youve utilized either Android or iOS, youre acquainted with applications sending you notices in any event, when theyre shut †those are message pop-ups. Sites can do something very similar regardless of whether youre not perusing them right now, as long as youve got your program running. Heres what a work area notice looks likeâ on Mac OS X:Push warnings can prove to be useful in a few circumstances, like:Notifying clients about new posts on your website.Letting supporters know when you addâ a new item toâ your eCommerce site.Making noteworthy declarations †concerning occasions and such †to your client base.Aside from these kinds of down to earth reasons, its significant that pop-up messages are an incredible apparatus to build client commitment [*]. The key is to refresh them just concerning significant stuff, so they wont begin disregarding your notices. Dont consider pop-up messages as a substitution for email records or int ernet based life channels. Theyre just another methods for direct contact, with the additional advantage of having the option to give ongoing updates to your visitors.How to set up WordPress message pop-ups (in 4 steps)Before we hop into the specialized stuff, its significant that you back up your WordPress site. You ought to consistently do this before including (or evacuating) any significant highlights from your site, in the event that something turns out badly. Indeed, you ought to do it routinely, regardless of whether you dont execute any huge changes. Look at ourâ guide on the best way to back up WordPress with a few options.For the reasons for this instructional exercise, well useâ the OneSignal module to set up WordPress message pop-ups. Its not by any means the only alternative out there, yet its one of our top choices. In the event that youd want to look at another option, investigate the Push Notifications for WordPress plugin.Step #1: Set up the OneSignal module OneSignal Web Push Notifications Author(s): OneSignalCurrent Version: 1.17.9Last Updated: October 1, sans 2019onesignal web-push-notifications.1.17.9.zip 82%Ratings 1,537,858Downloads WP 3.8+Requires OneSignal is a one-stop answer for WordPress pop-up messages. It underpins both work area customers (Chrome, Safari, and Firefox) and Android frameworks (theres no iOS support yet). Once empowered, your guests can pick in to get notices each time you distribute another post (or custom post types) through the WordPress proofreader or an outsider platform.The first thing we have to do is introduce and enact the module according to usual:When that is done, a OneSignal Push tab will show up in your WordPress dashboard. Snap on it, and youll be diverted to an arrangement tab to wrap up the module. Peruse the Overview and afterward head to the Chrome Firefox Push tab:The module incorporates bit by bit guidelines (with screen captures) for including the two administrations, so it is exc ess to rehash them here. Follow the methodology for Chrome and Firefox, and afterward head to the Safari Push tab on the off chance that you need to include those warnings also. Safari warnings just work on the macOS form, however, so keep that in mind.With that off the beaten path, gives up about adding WordPress message pop-ups to our website.Step #2: Configure programmed notificationsAs I referenced before, OneSignal WordPress pop-up messages possibly show up when you distribute new substance to your webpage. That incorporates both normal posts and custom post types. The module empowers you to set up warnings physically by ticking a crate close to the WordPress manager on your posts:If youd rather computerize this procedure, go to OneSignal Push Configuration in your WordPress dashboard. Presently look down and find the Automatic Notification Settings section.Turn on the primary alternative, as observed above,â etâ voilã . Your endorsers will naturally get warnings each ti me you distribute another post. You can likewise supplant the default OneSignal logo on the notices with your posts included pictures, by making a beeline for the Sent Notification Settings section:Enable the relating choice, and youre all set!Now its opportunity to arrange anâ opt-in for our notifications.Step #3: Add a warning select inOur WordPress pop-up messages are all set, however weve still got one stage to finish. Before clients begin getting warnings, they have to concur orâ opt into the program (subsequently the term select in). Here what an OneSignal pick in resembles on Safari:To do this, lets come back to OneSignal Push Configuration. Inside, find the Prompt Settings Notify Button section:The setting we have to turn on is first on the list: Automatically speedy new site guests to buy in to push notices. Do as such and afterward don't hesitate to mess with the remainder of the settings close to it. The Notify button alternative, for instance, empowers a little n otice button in the base right corner of your site, which empowers clients to check ongoing notifications.ConclusionWordPress message pop-ups are a successful apparatus that can expand your destinations commitment with little exertion. For whatever length of time that you continue delivering quality substance, it makes sense that clients will be keen on looking at it †all youre doing is giving them the intermittent suggestion to do so.If that seems like a triumphant recipe to you, here are the means you have to know to add WordPress message pop-ups to your site:Install the OneSignal plugin.Configure programmed notices utilizing the plugin.Set up a warning pick in for your visitors.What do you consider WordPress pop-up messages †would they say they are a contrivance or a valuable apparatus? Offer your suppositions with us in the remarks segment underneath!

Sumner, Charles

Sumner, Charles Sumner, Charles, 1811â€"74, U.S. senator from Massachusetts (1851â€"74), b. Boston. He attended (1831â€"33) and was later a lecturer at Harvard law school, was admitted (1834) to the bar, and practiced in Boston. He spent the years 1837 to 1840 in Europe. Later he became involved in several reform movements, including antislavery, and in 1851 a combination of Free-Soilers and Democrats sent him to the Senate. An aggressive abolitionist, Sumner attacked the fugitive slave laws, denounced the Kansas-Nebraska Act of 1854, and on May 19â€"20, 1856, delivered his notable antislavery speech called The Crime against Kansas. A master of invective, he singled out as his special victim Senator Andrew Pickens Butler of South Carolina, who was not there to reply. Two days later he was assaulted in the Senate chamber by Preston S. Brooks , Butler's nephew. It took Sumner more than three years to recover from the attack, but Massachusetts reelected him, and he resumed his seat in Dec., 1859. H e had been important in organizing the new Republican party and in 1861 was made chairman of the Senate foreign relations committee. In the Trent Affair he favored the release of the captured Confederate commissioners. Sumner highly approved Lincoln's Emancipation Proclamation; indeed he had been impatient at the long delay. Sumner in the Senate and Thaddeus Stevens in the House led the radical Republicans in their Reconstruction program for the South. He held that the Southern states had committed suicide by their secession and thus had lost any rights under the Constitution. Reconstruction he considered the function of Congress alone and he was most active in trying to secure the conviction of President Andrew Johnson on the impeachment charges. During the administration of Ulysses S. Grant, Sumner's excessive demands regarding Civil War claims against Great Britain hampered the administration's negotiations with that country. His relationship with Grant deteriorated furth er when Sumner denounced Grant's questionable scheme to annex Santo Domingo; this led to his removal (Mar., 1871) from the chairmanship of the committee on foreign relations. Humiliated, Sumner helped organize (1872) the short-lived Liberal Republican party . Sumner wrote and spoke widely, and there are two editions of his works (15 vol., 1870â€"83; 20 vol., 1900). See E. L. Pierce, Memoir and Letters of Charles Sumner (4 vol., 1877â€"93); D. H. Donald, Charles Sumner and the Coming of the Civil War (1960, repr. 1970) and Charles Sumner and the Rights of Man (1970). The Columbia Electronic Encyclopedia, 6th ed. Copyright © 2012, Columbia University Press. All rights reserved. See more Encyclopedia articles on: U.S. History: Biographies

Immigrant Families And The Parent Child Relationship Essay

Introduction The task of parenting is difficult for anyone. This task is even more difficult when examining immigrant families and the parent-child relationship. The population of first and second generation immigrant children in the United States grew by 51 percent between 1995 and 2014 (Child Trends, 2014, p. 3). According to the Migration Policy Institute, about 88 percent of immigrant children are born in the U.S (U.S. Census Bureau, 2014). While some immigrant children and their families are able to adjust to the United States smoothly, there is still a huge percentage of immigrant children who face a number of risks to healthy development. Immigrant children are more likely than non-immigrant children to live in families with a low socio-economic status, to have parents with low educational attainment and to have poor health (Child Trends, 2014). In addition to the risk factors that impact immigrant families, there are also dilemmas in the parent-child relationship. A major issue confront ed by immigrant children and their parents is the acculturation gap that emerges over time. Immigrant children are able to adjust relatively quickly to the new culture as a result of school and other activities. While immigrant children can quickly acquire to the values and behaviors of the host culture, studies have shown that immigrant adults retain their original culture, slowing their acculturation process (Liebkind, 1996). When the child’s adaptation exceeds that of theirShow MoreRelated Parenting Across Cultures Essay996 Words   |  4 PagesParents have their beliefs and practices when rearing their children, they share their customs and beliefs with their families to guide and support their families. Parents hope to share their practices from generation to generation, however when immigrants relocate other to countries they adapt to new ways of living (Two Parents, 2009). 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Thomas from The Pennsylvania State University who examines the progress of adopted foreign-born studentsRead MoreIn What Ways Has Each of your Identities Contributed to How You View Yourself?946 Words   |  4 Pages My current socioeconomic status is middle class however as a young child my socioeconomic status was low income. My mother was a single parent with four children. My mother Maria was unable to further her education since she had to work to help support her family. As she became an adult and had her own family she decided to migrate to the United Stated when I was 7 years old. She wanted a different life style for her family. My mother enrolled me in school at Woodlawn Elementary. A study conductedRead MoreImmigration Parents Stand As A Newcomer Essay986 Words   |  4 Pagesthat is dramatically more diverse than previous generations (Shields, Behram, 2004). Immigrant parents bring their values, language, culture, religion, and education backgrounds to our schools, enriching our educational environments (Guo, 2012). The challenges faced by many newcomer parents regarding their children’s schooling can be daunting (Bà ©langer, Dalley, Turner, 2015). This view that immigrant parents are not necessarily equipped to accompany their children with the homework help is typifiedRead MoreParental Power And Adult Authority1473 Words   |  6 Pagesmaking in the relationship and has a continuum that ranges from parental to child control. Types of parental power indicate the methods parents use to exert their influence on the child† (Vargas, Busch-Rossnagel, Montero-Sieburth, and Villarruel, 2000) . However, a recent study found that Hispanic children who are between the ages of four and six often struggle with depression, anxiety, and somatization due to common parenting styles within Hispanic culture (Cohen, 2015). 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After losing everything in China, Jing-mei’s mother, Mrs. Woo, tries as a minority house maid in the 1960s to provide all the opportunities she can for her last daughter. This short story revolves around the interactions between the Jing-mei, who desires a ordinary life, and Mrs. Woo, who seeks only the best from her daughter. The values of these two characters

The Crucible By Arthur Miller - 1952 Words

The Crucible by Arthur Miller was probably one of the most breathtaking plays of his time. Taking place during 1692 it talked about the Salem Witch Trials mostly, what happened, who was accused, how did it start, and how did it end. He did an amazing job describing the scenes, using actual names of the people at the time, and the actual events in chronological order. Throughout the play he also hit on a major idea during the time which was known as McCarthyism, where Arthur miller himself was accused of being a Communist. In addition with the creation of The Crucible came the creation of new ideas and new ways of interpreting plays. Themes such as reputation, religion, and revenge help people more easily interpret the play. Overall Arthur Miller has done many great plays, which sparked a chain reaction in making The Crucible and getting accused of being a Communist in the era of McCarthyism. â€Å"Arthur Miller [is known] as one of the leading playwrights of the 20th Century† (Arthur Miller). However his life wasn’t always that great. He was born in great poverty to a women’s clothing merchant that fell into a major economic disaster during The Great Depression. As he grew older he got more into literature and eventually wrote â€Å"one of the most famous political works of all time† (www.gradesaver.com/author/arthur-miller) known as The Crucible. However, with the creation of The Crucible came a cost only after 3 years it was published he was persecuted by everything he warnedShow MoreRelatedThe Crucible By Arthur Miller1269 Words   |  6 PagesAt first glance, the playwright Arthur Miller in The Crucible highlights the historical significance of the Salem Witch Trials of 1692, but in fact it is an allegorical expression of his perception of McCarthyism. If the reader has some background information on Arthur Miller’s victimization as a communist, it is evident that the play is a didactic vessel illustrating the flaws of t he court system in the 1950’s. The communist allegations were launched at government employees, entertainers and writersRead MoreThe Crucible By Arthur Miller1681 Words   |  7 Pagesof their way to the last dying breath to make sure they leave with a good or bad reputation. In one of the recent literature study in class â€Å"The Crucible† by Arthur Miller, Miller uses characterization to illustrate reputation throughout the play. â€Å"The Crucible† takes place in Salem, Massachusetts. It is based upon the Salem witch trails. In â€Å"The Crucible†, we journey through the life of three characters who reputations plays a major role in the play. The three characters are John Proctor, AbigailRead MoreThe Crucible By Arthur Miller998 Words   |  4 Pagesmotivated by jealousy and spite. The Crucible is a four-act dramatic play production that was first performed on January 22, 1953. Arthur Miller used dialogue within the characters to cover the multiple themes; conflicts and resolutions, plus the few directions for the different actions of the play. The Salem Witch Trials were intended to be performed as the play however, when read, it can be more carefully examined and broken down to analyze the techniques. Miller, the playwright, uses literaryRead MoreThe Crucible By Arthur Miller1333 Words   |  6 PagesAs the various characters in The Crucible by Arthur Miller interact, the dominant theme of the consequences of women’s nonconformity begins to slide out from behind the curtains of the play. Such a theme reveals the gripping fear that inundated the Puritans during the seventeenth century. This fear led to the famous witch-hunts that primarily terrorized women who deviated from the Puritan vision of absolute obedience and orthodoxy. Arthur Miller presents his interpretation of the suffering by subtlyRead MoreThe Crucible By Arthur Miller1145 Words   |  5 PagesUnbalance Through The Centuries In Arthur Miller’s play, The Crucible, the author reflects the persecution of communists in America in the 1950’s through a recount of the Salem witch trials. It is often presumed that Miller based his drama directly off of events that were particularly prevalent in the years surrounding the publication of The Crucible- which was released in the year 1953, towards the conclusion of the Korean War. Although there was not a literal witch hunt occurring during this timeRead MoreThe Crucible By Arthur Miller1063 Words   |  5 PagesIn the English dictionary, there are three definitions of the word crucible. One is a metal container in which metals are mixed and melted. Another is a severe test. But the third definition, and the one that I think fits the best for this book, is a place or situation in which different elements interact to create something new. In my mind, this fits because all of the characters had their little grudges and dirty secrets. But when all th ose seemingly little things interact, they formed somethingRead MoreThe Crucible By Arthur Miller1285 Words   |  6 Pages Rationale, Morality, Stereotypes, Pressure, Self-Censorship, Unanimity, and Mindguards. Groupthink has also taken place in our history a a country. The play, The Crucible by Arthur Miller is about a the real-life Salem Witch Trials that happened in 1692 - 1693, in Salem, Massachusetts. Some symptoms of Groupthink found in the Crucible are Rationale, Pressure, and Self-Censorship. The Groupthink symptom, Rationale, is described as when victims of Groupthink ignore warnings: they also collectivelyRead MoreThe Crucible By Arthur Miller841 Words   |  4 PagesThe Crucible is a chaotic play, throughout this American classic Arthur Miller takes the reader through multiple events of terror and insanity. While creating a great on-stage play, Arthur Miller portrays his life through the events, the characters, and plot of The Crucible. Using vivid imagery and comprehensible symbolism, Miller manipulates the real personalities of the characters and events in 1600 Salem, Massachusetts to create a symbolic autobiography. Throughout this play, the reader experiencesRead MoreThe Crucible By Arthur Miller811 Words   |  4 Pages While The Crucible, by Arthur Miller, is only a four act play, it still resembles the format of a five act play. The five-act structure evolved from a three-act structure, which was made famous by Roman Aelius Donatus. Donatus came up with thre e types of plays: Protasis, Epitasis, and Catastrophe. The five-act structure helped to expand the three act structure, mainly made famous by Shakespeare through his many tragedies. Even though The Crucible contains only four acts, it still has the commonRead MoreThe Crucible By Arthur Miller1052 Words   |  5 PagesBuddy Al-Aydi Ms.Healy English 9 CP 14th October 2014 The Crucible Essay The Crucible was a novel written by Arthur Miller in the 1950’s. It was written in a format of the play, portraying an allegory of the Salem Witch-Hunts led by Senator Joseph McCarthy. The book is known to have a inexplicable plot. This plot is advanced by multiple characters in the book in order to ensure that the reader maintains interest with the material that is being read. The farmer, John Proctor, would be the

Race, Class, Gender Free Essays

string(70) " first step in abolishing slavery by the African American population\." Danielle Karkkainen Prof. Shaleen Seward SOC. 301, Race/Class/Gender Writing Assignment December 4, 2012 â€Å"I am an American,† says over 308,745,538 people in the United States this year (â€Å"2010 Census Data. We will write a custom essay sample on Race, Class, Gender or any similar topic only for you Order Now â€Å") These people originate from everywhere; America is a â€Å"melting pot† of culture, and that can unfortunately cause social inequalities to arise through the Matrix of Domination, a theory that mirrors the intersectionality of race, class, and gender, as coauthor of Race, Class, Gender, an Anthology Patricia Hill Collins claims (Andersen, and Collins xi-xiii. These two terms give label to the commonplace phenomena of race, class, and gender work within a system of social relationships. The understanding of people from other cultures has grown in many ways over the history of the United States. America is starting to realize that the ethnocentric, or judging of others culture through the values of their own, is no longer an acceptable way to approach others. There is still a long way to go to more firmly develop a country with a general appreciation of diversity and inclusive thought. Knowledge is the power that will keep populations in peaceful, cultural awareness and harmonious equality. Anderson and Collins share many views of American life and morality through the different cultural perspectives of its citizens (and noncitizens. ) These articles prove that race, class, and gender all play separate, dynamic roles in the interrelated origins of discrimination. In the article, The Culture of Black Femininity and School Success, the realization that black women have historically been raised to consciously be more aggressively determined to succeed as they had the least amount of power in the education system. The conflict between young, black females and school officials usually ended up in a positive social change because the understanding that their race, class, and gender is constantly pinned up against them (Lewis, Mueller, and et al 187-193. ) In our patriarchal society, women lack power. In addition to that, these women are African American, which creates more issues in fighting against discrimination from those who have more power, such as a potential employer. Speaking of employment, black women in America generally come from a lower-class background, which works against them in gaining power to change their status in life. The people with power in America are generally the ones who don’t have issues obtaining wealth or status. This social construct has perpetuated many centuries, and today, it is seen most clearly by the white, educated males who are educated to become those with the power, that is, the white-collar employers and employees. On the flip-side of this case, minorities are educated in technical schools often, those with blue-collar or lower status jobs. For this, America has adopted laws like Affirmative Action as a protective measure to eliminate discrimination issues in the workplace. Some people think this law is unnecessary as â€Å"America means equality for all† however, this color-blind approach keeps those with the white privilege in ignorance (Gallagher 91-95. ) Inclusive thinking is necessary from a young age to create a more accepting atmosphere and society within the United States. To teach these concepts, the hidden agenda initiated from toddler-age on, which keeps the powerless under the thumb of the powerful must be eliminated. Understanding and accepting differences will be the easiest and most valuable, long-lasting way to boost the position of the powerless, i. . the minorities of America. Only when an equal percentage of minorities and Caucasian people obtain degrees and sufficient income will equality be a tangible possibility. American educational facilities have adopted the â€Å"Black History Month† as a role model for inclusion, however, why a single minority of a population have a single month of history created to what seems l ike a pacification of the lack of recognition of the importance of African Americans in America since the country’s birth. The hidden curriculum keeps social constructions of discrimination alive in our schools. We have a long way to go, as author Jeanne Theoharis proves in her article, â€Å"I Hate It When People Treat Me Like a Fxxx-up† the students of color in one school (as well, assumed in other schools) received unequal treatment, services, and materials because school officials believed the students did not care about their education. However, the minority students kept a journal of how important their education was and the tolerance of the unfair treatment toward the minorities was exposed and corrected (Theoharis 409. The idea that minorities, particularly African American, do not care about their education or are a â€Å"problem population† because of their race, and the typical disadvantages that come along with that is primitive. From the days of Harriet Tubman and slavery, to the powerful resolution of Rosa Parks, to the incredible civil rights acts in the 1960’s, to the most wealthy woman in America being African American, black people have changed their fa ce and the face of our history throughout time. African Americans have a type of double consciousness created by society. The majority (white people,) have created a belief shared amongst much of the black population on some kind of level. This perspective is that of an acceptance of a secondary race and not as worthy as Caucasians. The other perspective that may be what powers the young, black female in particular as aforementioned is that of strength and faith. The African American community has always had a strong connection with one another, yet excluded from the mainstream of America. In the days of slavery, the seeds of this double consciousness were planted in the African American culture. Upon rowing on overcrowded ships, ill with plague, and maliciously beaten by the white man, Blacks began to see themselves as white people did- property. This was the lowest point in African American history, and many black people rose as a type of â€Å"Over-Man† in order to save their people’s culture and lives. Harriet Tubman saved hundreds of different African Americans from slavery by hiding them in an underground tunnel to the more free North, which was the first step in abolishing slavery by the African American population. You read "Race, Class, Gender" in category "Papers" Many years after slavery of African Americans ended, Jim Crow laws still segregated the minority group from the rest of society. Jim Crow laws were not necessarily legal, nor written, but they were implied, and explicitly enforced. These laws kept the less powerful African Americans away from and in service to white Americans. In the 1940’s and 1950’s, America’s law of the land was â€Å"Separate but Equal,† meaning there were separate areas for facilities, separate lines for tickets, restricted seating, etc. This was further obvious through the lack of proper education for African Americans. If Jim Crow laws were broken, African Americans were severely punished. This could have mean hate beatings, lynching, or imprisonment. Representation of African Americans was entirely lacking and causing a rising tension between the rivaling African Americans and white Americans. With rising violence and aggression, leaders such as Malcolm X and Rev. Dr. Martin Luther King, Jr. arose with two separate types of action calls for African Americans. Muslim activist Malcolm X proposed progression at any cost. Linked with the Black Panthers, a lower-class black activist group, violence was encouraged if peace did not reap reward and cost this leader his life. This caused many riots, resulting in police brutality and discrimination towards people of color. The Hammurabi-like code â€Å"an eye for an eye† approach does not work when attempting for understanding and acceptance. For this, Martin Luther King proposed a solution to the racial discrimination to end. This was to keep a steady, calm head and proceed with absolute resolution to positive social change and peaceful rioting. This approach seemed to work better, although only with complete determination and self-control. After many marches, protests, and exchanges, as well as Dr. King’s assassination, the power of black Americans was starting to be recognized by the world. The Equal Employment Opportunity Committee was created in 1967 to assist minorities receive the jobs they deserve, reviewing and protecting applicants from employer discrimination. This created over 4,000 injuries in ensuing riots and a revived call to action for equal treatment of minorities (â€Å"Jackson Sun. ) This was the result of yet another attempt at equality for all American citizens. However, this attempt joined forces with the Affirmative Action law President John F. Kennedy created in order to stop racism bleeding into the employment world. Giving black Americans more power, the social class of African Americans rose for a decade before hitting a bump in the progression of African American historical timeline when c rack cocaine hit the streets along with the influx of HIV/AIDS. African Americans were amongst the hardest hit by these two pandemics. Bringing African American morality down, and degrading back to the poverty lifestyle, gangs boomed, creating a family unit and source of income for many urban African Americans. In the 1990’s, gang violence skyrocketed. In direct opposition, so did police brutality, particularly of African Americans. The teachings of gang members grew exponentially through the powerful words of American rap by gangsters like Tupac Shakur and Biggie Smalls, who both grew up in the slums of opposing American coasts and shared the horrific life occurrences they witnessed or took part in. Not only did these artists glamorize the thug lifestyle, but the women in the music videos of these artists created a further degradation of females as sexual objects, not humans to be respected. Tupac addressed these issues with his poetry: â€Å"I see no changes wake up in the morning and I ask myself Is life worth living should I blast myself? I’m tired of bein’ poor even worse I’m black My stomach hurts so I’m lookin’ for a purse to snatch Cops give a damn about a negro Pull the trigger kill a ***** he’s a hero Give the crack to the kids who the hell cares One less hungry mouth on the welfare First ship ’em dope let ’em deal the brothers Give ’em guns step back watch ’em kill each other It’s time to fight back that’s what Huey said† (Changes. ) This is an explicit example of the war-like lifestyle African Americans maintained in the streets of urban centers. Police officers and government officials were discriminating against African Americans more than any other minority. The consistent oppression of black people lead by police roused many riots. Perhaps the most well-known of all instigators of civil rights call to actions is the infamous 1992 Rodney King beating. Four police officers beat Rodney King, a mad guilty of a DUI until he had broken 11 facial bones, among other injuries (â€Å"Rodney King. â€Å") Americans were outraged by the unnecessary brutal treatment of this man and deemed it an extreme example of police discrimination. This tension between African Americans and police officers created 53 deaths, 2,383 injuries, more than 7,000 fires, damage to 3,100 businesses, and nearly $1 billion in financial losses (â€Å"Rodney King. â€Å") Finally, African Americans were making their case for equality known. The United States has just re-elected Democrat, Barack Obama for a second term in office. This man is half African American, half Caucasian. It is almost unfathomable that we finally have a man of color in the Oval Office upon seeing the constant failures of activists who desire to see equality for all. These â€Å"failures† are not what they seem, as collectively, they catapulted African Americans to a much more comfortable position in the United States. Just because our President is half black does not mean the fight for African American equality is over. Unfortunately, there are still plenty of hate crimes heard in the headlines are the country to this day. African Americans are gaining status in society now that there are much more firm laws in place deterring employers, instructors, or officials to discriminate based on race, class, gender, or orientation. In the near future, the minorities of America will no longer be considered the minority as our global as well as country-wide population is ever-changing and increasingly becoming more well-rounded. Hopefully, this will assist in eliminating the hate crimes, prejudice, and discrimination against those who do not have the luxury of inherently obtaining the white privilege. Understanding that race, class, and gender all works for and against us constantly due to social construct will create a more positive awareness of the importance equality and the beauty of each individual’s unique qualities, experiences, and characters. Race, class, and gender still remains unequal amongst American individuals, so teaching positive social change and appreciation of a multicultural society will always remain a necessity. Works Cited Andersen, Margaret, and Patricia Collins. Race, Class, Gender. 8th ed. . Belmont: Wadsworth Cengage Learning, 2010. xi-xiii. Print. Gallagher, Charles. â€Å"Color-Blind Privilege. † Trans. Array Race, Class, Gender. Margaret Anderson and Patricia Collins. 8th ed. Belmont: Wadsworth Cengage Learning, 2010. 91-95. Print. Lewis, R. L, Jennifer Mueller, et al. â€Å"The Culture of Black Femininity and School Success. † Trans. Array Race, Class, Gender. Margaret Andersen and Patricia Collins. 8th ed. Belmont: Wadsworth Cengage Learning, 2010. 187-193. Print. â€Å"National Civil Rights Timeline. † Jackson Sun [Jackson] 2003, n. pag. Web. 2 Dec. 2012. . â€Å"Rodney King. † 2012. . Shakur, Tupac, writ. Changes. 1998. Song. 1 Dec 2012. Theoharis, Jeanne. â€Å"I Hate It When People Treat Me Like a Fup. † Trans. Array Race, Class, Gender. Margaret Andersen and Patricia Collins. 8th ed. Belmont: Wadsworth Cengage Learning, 2010. Print. United States. U. S. Census Bureau. 2010 Census Data. Washington, D. C. : , 2012. Web. . How to cite Race, Class, Gender, Papers

The United States Government Efforts to Combat with Obesity

Background Over the last fifty years, there has been a growth in obesity in the United States of America, children are the most affected; according to U.S. Department of Health Human Services report of 2007, over 25% of American children are obese, while more than, 60% of the population was either overweight or obese. The alarming increase is because of the living standards adopted of late by the residents in the country (Keller, 2008). This report evaluates the efforts put by the United States government to combat the spread of obesity.Advertising We will write a custom essay sample on The United States Government Efforts to Combat with Obesity specifically for you for only $16.05 $11/page Learn More Thesis Statement Because of  prevalence of obesity in the United States, the ministry of health has developed a number of policies that target the nutritional disorder in the country. The approach that the government has taken can be interpolated into tw o dimensions: pharmacological interventions and lifestyle interventions, the main aim of the interventions is to reduce the spread of the epidemic and alert the population on the dangers of the disease. Pharmacological interventions Although obesity is a nutritional disorder, medical practitioners have an intervention to the cure of the disease, the intervention may not necessarily be to offer medicine to the people suffering from the disease but to create an awareness of the dangers that the disease is likely to cause on someone from a medical perspective. At extreme case, the government has established an obesity center where patients can be attended to and given medications and surgery services to assist in the cure of the disease. Some accumulation of fat can be removed through operation and use of medication; these cases are addressed by obesity problems in the country to ensure that the suffering population gets proper medical attention. On the other hand, there are a number o f health disorders brought about by obesity; the government is improving its capacity to cater for these emerging cases. Lifestyle interventions Obesity is sometime regarded as a lifestyle disease, it is caused largely by the kind if foods that people eat and the lifestyle they adopt. When people eat junk foods, they increase the chances of getting the disease. Junk have a large accumulation of fat, form their processing and their own nature. The ministry via national media tools and nongovernmental organs has embarked on massive campaigns against eating of junk food and eating proper foods. They are teaching the people on how to eat healthy and the benefits that eating healthy is lily to bring to their lives; this is in the efforts of enacting policies that lead to behavior change.Advertising Looking for essay on health medicine? Let's see if we can help you! Get your first paper with 15% OFF Learn More The ministry is using every available opportunity to offer nutri tional educations, for example when a mother has delivered; they are advised on how they should feed their children as well as the eating habits they should enforce. Businesses that sell fast foods have been controlled in the country and the government controls their marketing campaigns. For example when advertising for junk foods, the companies are controlled not to target children directly. The cost of junk foods have been increased through government policies in the country like taxation, their number has also been limited. The United States Ministry of Health in collaboration with Ministry of Education is developing exercising programs through games to children. The aim of the programs is to encourage outdoor activities; when children engage in such programs, then they are less likely to suffer from obesity (U.S. Department of Health Human Services, 2011). Conclusion Obesity is a growing problem in the United States, in recognition of the dangers likely to result from obesity, the government through the Ministry of Health has started programs to prevent the spread of the disease and cure the suffering population. The government has a two dimensional approach, the dimensions of the approach are: pharmacological interventions and lifestyle interventions. References Keller, K. (2008).  Encyclopedia of Obesity. Thousand Oaks, Calif: Sage Publications, Inc U.S. Department of Health Human Services. (2011). Improving Care for Medicare Patients. Retrieved from https://www.hhs.gov/ This essay on The United States Government Efforts to Combat with Obesity was written and submitted by user Blaine U. to help you with your own studies. You are free to use it for research and reference purposes in order to write your own paper; however, you must cite it accordingly. You can donate your paper here.

WATCH What a CEO looks for in your job interview

WATCH What a CEO looks for in your job interview When interviewing for a new position, nothing can be more beneficial than knowing beforehand what you need to do to be successful during your initial time with your prospective employer.Daily Fuel sat down with an expert on the subject and one of the leading marketers in the United States, HelloWorld CEO Peter DeNunzio, who details what he looks for most when interviewing potential additions to his team. Source: [Daily Fuel]

States Where Recreational Marijuana Use Is Legal

States Where Recreational Marijuana Use Is Legal Eleven states have legalized  recreational marijuana use  in the United States. They are Alaska, California, Colorado, Illinois, Maine, Massachusetts, Michigan, Nevada, Oregon, Vermont, and Washington.  Washington, D.C., also allows the recreational use of marijuana.   They are among 30 states that allow the use of marijuana in some form; most others allow for use of the substance for medicinal purposes. The eleven states where recreational use is legal have the most expansive laws on the books.   Here are the states in which marijuana use is legal. They do not include states that have  decriminalized the possession of small amounts of marijuana  or states that allow the use of marijuana for medical purposes. It is also important to note that growing and selling marijuana is illegal under federal law, though that rule is not enforced by the U.S. attorney general. 1. Alaska Alaska became the third state to allow recreational marijuana use in February 2015. The legalization of marijuana in Alaska came by a ballot referendum in November 2014, when 53 percent of voters supported the move to allow use of the substance in private places. Smoking pot in public, however, is punishable by a modest fine of $100. Private use of marijuana in Alaska was first declared a right in 1975 when the state Supreme Court ruled that possessing small amounts of the substance was protected under the state constitutions guarantee of the right to privacy. Under Alaska state law,  adults 21 and older can carry up to an ounce of marijuana and possess six plants. 2. California California state lawmakers legalized the recreational use of marijuana with the passage of  Proposition 64 in November 2016, making it the largest state to legalize pot. The measure had the support of 57 percent of the legislature. Sale of marijuana became legal in 2018. Cannabis is now legal in the most populous state in the country, dramatically increasing the total potential size of the industry while establishing legal adult use markets across the entire US Pacific Coast given the legalized states of Washington and Oregon, stated New Frontier Data, which tracks the cannabis industry. 3. Colorado The ballot initiative in Colorado was called Amendment 64. The proposal passed in 2012 with support from 55.3 percent of voters in that state on Nov. 6, 2012. Colorado and Washington were  the first states to legalize recreational use of the substance. The amendment to the state constitution allows any resident over the age of 21 to possess up to an ounce, or 28.5 grams, of marijuana. Residents can also grow a small number of marijuana plants under the amendment. It remains illegal to smoke marijuana in public. Also, individuals are not able to sell the substance in Colorado. Marijuana is legal for sale only by state-licensed stores similar to those in many states that sell liquor. Colorado Gov. John Hickenlooper, a Democrat, officially proclaimed marijuana legal in his state on Dec. 10, 2012. If the voters go out and pass something and they put it in the state constitution, by a significant margin, far be it from myself or any governor to overrule. I mean, this is why it’s a democracy, right? said Hickenlooper, who opposed the measure. 4. Illinois The states General Assembly passed the Illinois Cannabis Regulation and Tax Act on May 31, 2019, and it was signed by Gov. J.B. Pritzker on June 25. The law goes into effect on Jan. 1, 2020. It allows Illinois residents at least 21 years old to possess up to 30 grams of marijuana. The limit is 15 grams for non-residents. 5. Maine Voters approved the Marijuana Legalization Act in a 2016 referendum. Individuals can possess up to 2.5 ounces (71 grams)  of cannabis, up to three mature plants, 12 immature plants and an unlimited number of seedlings. The state did not, however, begin issuing commercial licenses to sell the drug immediately because state lawmakers could not agree on how to regulate the industry. 6. Massachusetts Voters legalized recreational marijuana in November 2016. Individuals can possess up to one ounce of cannabis and grow up to six plants at their homes. Homes with more than one adult can grow up to 12 plants. Pot must be locked up and not visible in cars, and smoking while driving or in public is illegal. The states Cannabis Advisory Board continues to work on regulations but is reportedly planning to allow use of the substance in retail spaces, unlike most other states.   7. Michigan Voters legalized the recreational use of marijuana in November 2018. The Michigan Regulation and Taxation of Marijuana Act allows individuals to possess up to 2.5 ounces of marijuana outside their home and 10 ounces inside their home. Up to 12 plants per household  are allowed. Licensed retail businesses can grow up to 150 plants for sale. 8. Nevada Voters passed Question 2 in the 2016 election, making recreational marijuana legal as of 2017. Adults ages 21 and older can possess up to one ounce of cannabis and up to an eighth ounce of concentrate. Public consumption is punishable by a $600 fine. The measure had support from 55 percent of voters. 9. Oregon Oregon became the fourth state to allow the recreational use of marijuana in July 2015. The legalization of marijuana in Oregon came by ballot initiative in November 2014, when 56 percent of voters supported the move.  Oregonians are allowed  to possess up to an ounce of marijuana in public and 8 ounces in their homes. They are also allowed to grow as many as four plants in their homes. 10. Vermont The state legislature passed HB511 in January 2018, which allows an individual to possess one ounce of cannabis and two plants. No commercial sales are allowed. The law took effect on July 1, 2018. 11. Washington The ballot measure approved in Washington was called Initiative 502. It was very similar to Colorados Amendment 64 in that it allows state residents ages 21 and older to possess up to an ounce of marijuana for recreational use. The measure passed in 2012 with the support of 55.7 percent of voters in the state. The Washington ballot initiative also put in place substantial tax rates imposed on growers, processors, and retailers. The tax rate on recreational marijuana at each stage is 25 percent, and the revenue goes to state coffers. District of Columbia Washington, D.C., legalized the recreational use of marijuana in February of 2015. The measure was supported by 65 percent of voters in a November 2014 ballot initiative. If youre in the nations capital, youre allowed to carry up to 2 ounces of marijuana and grow as many as six plants in your home. You can also gift a friend up to an ounce of pot.

Management Strategies Essay Example | Topics and Well Written Essays - 1750 words

Management Strategies - Essay Example This can, in part, be contributed to past analysis which has effected in a study of decision making behaviour. This analysis by various scholars has depicted the fact that decisions regarding risky organisational decisions brings out contradictory reactions. Here, we can find the essence of the dichotomy that risk taking strikes as a major aspect of business activities. Risk, in case of such decisions, is seen as a focus of single determinants of behaviour arising from risk theories. Although this approach does not conform to real life situations in an obvious fashion, it has led to potentially inaccurate conclusions about risk behaviour. Such unresolved contradictions can be reconciled by examining the usefulness of placing risk propensity and risk proportion in a more central role than has been previously recognised. Based on such analysis, it is believed that the propensity of risk dominates both the actual and perceived characteristics of the situation as a determinant of risk behaviour. Such an observation can safely justify the finding that suggests that apart from being central to any and every business or organisation, risk is something that entrepreneurs in general, are averse to. This brings us to a discussion on business and kinds of risks. Business can be conducted in any sphere of the earth - literally. Today we have a plethora of businesses on land apart from the ones on water and in air. Apart from the normal business activities, one can find airlines and maritime organisations emerging as major sectors. If we are to take the example of maritime, it is the oldest sector in terms of innovation and discoveries. There have been perils to overcome, risks to undertake, more powerful vessels to make each time, and even more powerful contracts to insure and protect the maritime entrepreneurs, as we are going to refer to these 'shipmen' in the course of this paper. Marina organisations today have spread their wings beyond mere cargo vessels and are now running good profits in the sphere of luxury liners, etc. With risks and businesses come allied industries. Insurance and financial risk management are major industries that thrive side by side with any sector in the world, for there is no area that has been spared the occurrence of risks and accidents as well as catastrophes. Maritime activities hold the promise of enormous risks, which can be analysed in its various aspects as follows, from the insurance point of view: Type and size of boats using the marina New industries established in adjacent areas Changes in the international and national regulatory environment Marina 3 Aging of the marina infrastructure Recent waterfront development Changes in response to equipment, technology and availability Logistics Identification of human and natural resources Trends in political climate and global economy These points besides being self explanatory are relevant in context of the current state of affairs. They have every potentiality of developing from minor to major crises, which explains the development and growth of the field of financial risk management. This can be attributed to the fact that at the end of the day, any loss has financial implications of its own and is deeply rooted in the genesis of risk taking and management. The above mentioned points, with a strong background of financial

Discuss and assess the parallels between cold war anti-communism and Essay

Discuss and assess the parallels between cold war anti-communism and contemporary debates about terrorism and border protection - Essay Example apparently aimed at protecting human rights by inculcating political sovereignty in the so-called ‘failed states.’ Apart from a few isolated murmurings in the West, these experiments in state-building, humanitarian intervention and policing of wayward nations were neither openly associated to an American empire nor were they labelled as imperialist. The arrival of George Bush at the White House and the terrorist atrocities of September 11, 2001 reveal the role of the U.S. in the global economy. Furthermore, the war on terror that ensued shortly after September 11 seem to have reversed the world order and ignited a debate on the role of the U.S in fostering international peace. The debate presented in this paper argues that the U.S. role seems to have accorded itself the role of maintaining a check on communism (Bamford, 2004: pp 18-47). The paper aims at exploring the analytical and historical value of the connection between terrorism, war, efforts at border protection a nd the efforts at taming communism and fostering the extension of the American empire. Some of the historical questions that the paper aims to solve include the role that the Cold War played in shaping a domineering American empire. There is also an attempt to analyze how the nature of this empire was affected by the end of the Cold War. Therefore, the paper aims at presenting a comparison between the prevailing conjecture of border protection measures and the war on terror with the origins of the rivalry between capitalism and communism. Researchers have done a critical analysis of several theoretical perspectives that shed more light on the underlying dynamics in the aggravated efforts to fight terrorism in the world.. These perspectives also highlight how these dynamics serve to entrench border protection measures, especially after the end of the Cold War. The first perspective regards to the theory of realism which emphasizes several motives that are connected to the power, national

The Manufacturing Of DNA Vaccines

The Manufacturing Of DNA Vaccines A detailed design and layout of the facility for the manufacturing of DNA vaccines was developed. The factors foremost in the design and layout of the DNA vaccines facility were compliance to current good manufacturing practices (cGMP), regulatory guidelines, health, safety and environment, effective production, optimum material and personnel flow, effective cleanliness, minimisation of contamination and enhance maintenance. The total site area is 108m X 91m (9828m2) and plant/production area is 32m X 20m (640m2) with space for future expansion. To reduce the impact of airborne particles, relative humidity, pressure and temperature on the purity, efficacy, and safety DNA vaccines product, a containment/cleanrooms of class 100 was design with controlled-air environment with access via airlock, HVAC and high efficiency particulate air (HEPA) filters. In order to conform and comply to current good manufacturing practices (cGMP) and regulations, the following key component of cGMP were i ncorporated into the design, validation master plan (VMP), standard operating procedures (SOPs), appropriate quality control (QC), cleaning-in-place (CIP), sterilisation-in-place (SIP), trained personnel, documentation, health, safety and environment, utilities required and waste treatment process. The entire project timeline was estimated with the aid of Gantt chart project management technique to be a year and 4.5 months with reference to literatures on similar projects. 1.1 Introduction The demand for DNA vaccines for gene therapy, vaccination and for the treatment of diseases such as cancer, malaria, swine flu, HIV, melanoma, etc. is on the increase (Prather et al., 2003; Williams et al., 2009). This is because DNA vaccines triggers cellular and humoral immune responses, safe and stable (Prather et al., 2003). Therefore, there is need to design manufacturing facility for DNA vaccines production to meet the rising demand. However, the design, operations and layout of the manufacturing facility must conform and comply to standards, specifications and guidelines stipulated by regulatory authorities such as the U.S. Food and Drug Administration (FDA), Medicines and Healthcare products Regulatory Agency (MHRA), European Medicines Evaluation Agency (EMEA), World Health Organisation (WHO) and the regulation of the country in which the facility is to be constructed. In addition to meeting this regulations and guidelines the DNA vaccines production process, design and premi ses of its manufacture must conform to good design practices (GDP) and current good manufacturing practices (cGMP) (Shamlou, 2003; Przybylowski et al., 2007). The commercial scale production of DNA vaccines is justified by economics/cost, health, safety and environment, compliance to legal standards and production under Good Manufacturing Practices (GMP) (Shamlou, 2003). This is to ensure that manufacturing processes are controlled and performed according to design specifications and operational procedures in order to ensure that quality is built into the product (DNA vaccines) to assure safety, efficacy, purity and identity consistently (Przybylowski et al., 2007). In addition, GMP requirements are open ended, however the International Society of Pharmaceutical Engineers (ISPE) has enumerated the principal steps to current GMP which include standard operational procedures (SOPs), qualification and validation of process performance, design, quality control testing, adequate process control, sterilization in place (SIP), cleaning in place (CIP), layout design, quality management, documentation and audit of facility as necessary to ensuring specification and maintenance of product identity and compliance to regulations (WHO, FDA, MHRA, etc.) and current good manufacturing practices (cGMP) (Day, 2004). The issue of location for the manufacturing facility is crucial to its profitability as it is influenced by raw material supply, transportation, utilities, environmental impact, waste disposal, local community considerations, personnel, climate, plant size and availability of land (Sinnott, 2005). Moreover, before the design and installation of a new facility for pharmaceutical and biopharmaceutical product manufacture, an environmental impact assessment (EIA) is perform and approved (Davda, 2004). Hitherto, the design of any manufacturing facility must integrate the design of a treatment process and safe disposal of the waste generated to specified legal standards by regulatory authorities and eliminate/minimise harm to health and safety of personnel, environment and product contamination. The manufacturing facility layout must be designed to aid good raw material flow, waste flow and personnel flow around the factory to reduce risk, cross contamination and ensure that production ac tivities and factory operations are performed smoothly and follow a defined procedure. The pharmaceutical manufacturing process must be conducted in clean environment and clean rooms in which the temperature, pressure, air borne particles and relative humidity are controlled to specified conditions by regulators (U.S. FDA, WHO, ISO, MHRA, etc). All these are the component of current Good Manufacturing Practices (cGMP) to build quality assurance, consistency and safety of therapeutic product (DNA vaccines) to human life (Signore and Terry, 2008). The entire operations and activity should be performed by trained and competent personnel and quality management for a satisfactory quality assurance (QA/QC). 1.2 Aims and objectives 1. The defined goal of this project is to develop a detailed design and layout of a manufacturing facility for the production of DNA vaccines for commercial scale, applying current Good Manufacturing Practices (cGMP) and in compliance to regulatory guideline (FDA, FDA, MHRA, WHO, etc.). 2. Provide detail methods for qualification and validation of the design and layout, performance, quality control and enumerate the personnel/staff involved in the project. 3. Estimate the timeline of the project. 2.1 Process overview DNA vaccines production mainly starts on a bench scale through pilot scale to large scale production (Ferreira et al., 2000; Bequette et al., 2004). The design of a large scale facility for the manufacturing of DNA vaccines involves the selection of suitable plasmid DNA constructs/vectors (ColE1-type vectors, pUC vectors, pBR322 plasmid vector, etc.) that will replicate at high copy numbers, the production microorganism cell bank (Escherichia Coli), subsequently followed by fermentation process in the bioreactor under optimum conditions and control media (temperature, pH, pressure, etc.) to maximise cell growth, cell lysis to break the cells to release the DNA, isolation by precipitation of genomic DNA, cell debris, proteins and RNA, purification by anion exchange chromatographic technique because DNA is negatively charged, formulation and blending, sterile filling, packaging and storage in the fridge (Ferreira et al., 2000; Prather et al., 2003; Przybylowski et al., 2007).   2.2 Design of flowsheet The conceptual design of the process flowsheet for DNA vaccines production under cGMP was based on the knowledge of the process block diagram in Fig.1 above and the performance of the associated unit operations. The process flowsheet shown in Fig.2 is interconnection of the various unit operations, fermentation, the downstream processing (cell lysis, precipitation, clarification and concentration, primary purification (anion-exchange chromatography) and secondary purification (size exclusion chromatography)) and blending and formulation of the bulk product into usable form (Prazeres and Ferreira, 2004). Each pieces of equipment in the process flow sheet are designed to conform and comply with standard and code of practice of either International Organisation for Standardization (ISO), British Standard Institution (BSI), American Petroleum Institute (API), American Society for Testing Materials (ASTM), American National Standard Institution (ANSI), etc. to ensure safety, selection of suitable material of construction, and also equipment manufacturers work to produce facilities according to standardized design and size (Sinnott, 2005). Also each pieces of equipment are hygienically designed with good polished surfaces and piping for easy CIP and SIP, elimination of dead zones and sharp edges to avoid microbial growth and contamination and constructed with stainless steel material to eliminate contamination. The final product DNA vaccines are sterilely filled into vials and stored at -20oC in the freezer (Przybylowski et al., 2007). 3.1 Site layout design The site layout was designed to prevent product contamination, environmental pollution and to safeguard the health and safety of personnel. The various unit operations shown on the process flowsheet in Fig.2 and the ancillary buildings required to support the manufacturing facility for DNA vaccine production are laid out to give an economical flow of raw materials to final product storage, flow of personnel and waste around the production site to conform to good manufacturing practice (GMP), reduce risk and product contamination (Sinnott, 2005; Signore and Terry, 2008). The site layout design in Fig.3 was done with consideration to future expansion of the DNA production. Clean rooms, waste treatment area, hazardous process and raw materials were isolated and arranged for safety of product, personnel and environment. The size of the site is 108m X 91m (9828m2) as shown in Fig.3 and the ancillary buildings and support services required for the manufacturing facility are: Storages for raw materials and DNA vaccines. Quality control laboratory. Maintenance workshops and warehouse. Utilities: steam, compressed air, power generation, refrigeration, water (WFI), CO2, N2 etc. Cleaning-in-place (CIP) and Sterilisation-in-place (SIP). Effluent treatment and disposal plant. Process control room Administrative offices Fire stations and other emergency services Amenities required include: roads and car parks, first aid centre, canteen, security, rest room, changing room, training room and visitors centre. 3.2 Facility layout design The detailed design and layout of the DNA vaccines production rooms and equipment is designed to minimise risk, reduce cross contamination, permit effective cleaning and sterilisation of external and internal surfaces of process equipment by the use of clean in place (CIP) and sterilisation in place (SIP), enhance maintenance and control of clean rooms temperature, pressure and relative humidity (RH) under standard operating procedures (SOPs) (Przybylowski et al., 2007). The facility layout design also considered the cleanrooms, equipment and the flow of materials and personnel as key factors that impact on manufacturing cost, operational procedures and productivity (Drira et al., 2007). The DNA vaccines manufacturing facility layout design is 32m X 20m (640m2) in size as shown in Fig.4 to ensure efficiency and safety of the production environment and manufacturing process which are dependent on the layout of the facility (Jacobson et al., 2002). 3.2.1 Cleanrooms/containment design One of the principles of GMP is cleanliness and aseptic operations to prevent product contamination by microorganisms, particulate generated during plant operations and changes in room conditions (temperature, relative humidity, etc.). Therefore, DNA vaccines which are biological drugs are manufactured in clean rooms, that is, a room in which the air quality (airborne particles), the temperature, the pressure and relative humidity are controlled to prevent contamination by impurities, dust and microorganisms in the atmosphere and in the ambient air, in order to protect its purity, efficacy and safety (Sutherland, 2008). The layout and design of the production rooms was according to the International Standards Organisation (ISO) 14644-1 cleanrooms classification shown in Table 2 below. The raw materials, fermentation, purification, blending and formulation and product storage clean rooms are designed for class 100 biosafety cabinet fitted with high efficiency particulate air (HEPA) fi lters and HVAC systems to ensure the entry of clean air into the cleanrooms and exit of dirty air inside the rooms (Sutherland, 2008). The flow of air in and out of the cleanrooms is laminar. Other components of the cleanrooms include: Separate airlocks for entry and exit doors for personnel, raw materials and waste products. An inlet port for fresh purified air. An exit vents fitted with activated carbon filter to purify contaminated air before discharge to ensure environmental safety (Sutherland, 2008). Cleanrooms air pressure is maintained below atmospheric to prevent outward leakage. Nonslip floors, electricity, light appropriate and aseptic processing hood. Humidifiers to maintain and control cleanrooms relative humidity and temperatures 4.1 Raw materials Variations in raw materials composition is known to impact on the quality of DNA vaccines produced and also the operations of the plant. Therefore, raw materials require quality control check before used. The raw materials, reagents and utilities required for the DNA vaccines manufacturing facility are: plasmid DNA vectors, nutrients, glucose, water for injection (WFI), sterile air, salt, buffer capacity (to stabilise pH of fermentation), liquid nitrogen N2, and antibiotic, alkaline, master cell bank (MCB) and working cell banks (WCB). These are placed in the quarantine storage room and undergo quality control testing to ensure that specification are met before used for DNA vaccines production for quality assurance (QA/QC). The flow of materials from the raw materials to the final product (DNA vaccines) is shown in FIG. above and the final DNA vaccines products are stored in a sterile room in a freezer at -20oC (Przybylowski et al., 2007). 4.2 Personnel The compliance to current good manufacturing practices (cGMP) and regulatory guideline depends on people and good management structure. It is essential when developing new facility to integrate all relevant personnel from production, logistics, quality control and engineering in the inception phase of the design and layout. Therefore, for a satisfactory quality assurance of the DNA vaccines production, facility design and layout, the interactions and inputs from various disciplines such as chemists, chemical engineers, biochemical engineers, biologists, microbiologist, pharmacists, civil engineers, project managers, mechanical engineers, electrical engineers, architect, cost engineer and many others are required to carry out defined tasks and responsibilities. The flow of personnel around the designed facility layout during operations is shown in FIG. 4.3 Qualification and validation The qualification and validation of pharmaceutical manufacturing facilities at regular intervals is an integral part of good manufacturing practices (GMP). This is documentary evidence that assures that the DNA vaccines production facility is performing satisfactorily and consistently to specification for the intended purpose (Day, 2004). To do this, a validation master plan (VMP) is drawn up which include: design qualification (DQ), installation qualification (IQ), operational qualification (OQ) and performance qualification (PQ) to confirm that all was done according to specifications (Day, 2004; Chaloner-larsson et al., 1997). However, an internal audit of the facility and instruments is also conducted to ensure compliance and implementation of cGMP and regulatory guidelines. 4.3.1 Design qualification (DQ) Design qualification is carried on the following production pieces of equipment of the manufacturing facility such as bioreactor, centrifuge, anion-exchange chromatography, size exclusion chromatography, microfiltration system, ultra-filtration system, HVAC systems and lyophilizer, for verification and documentation as a prove to show that the equipment designs conforms to regulatory standards such as ISO 9000, BSI, etc. 4.3.2 Installation qualification (IQ) The IQ is a documented verification that confirms that the manufacturing facility layout, HVAC systems, supporting utilities (steam, CIP, SIP, etc.) and process equipment are built and installed in compliance to the designed specification and manufacturers recommendations (Chaloner-Larsson et al., 1997). The IQ document for each equipment/system contains name of equipment/system, description, model and identification number, the location, utility requirements, any safety feature, date, personnel and approver. 4.3.3 Operational qualification (OQ) The OQ is the documentary verification of the manufacturing facility to confirm that each pieces of equipment operates in accordance to designed specifications and operation conditions and will consistently (Day, 2004). This is accomplished by testing control systems, alarms, switches, and providing standard operations procedures (SOPs) for the operations of the manufacturing facility. 4.3.4 Performance qualification (PQ) Performance qualification (PQ) is a documented verification that confirms that the manufacturing facility and the supporting utilities will consistently perform to required specification under the designed operating ranges to production the DNA vaccines. The following systems and pieces of equipment are validated for performance check: purification processes, bioreactor, HVAC systems, autoclave, CIP, SIP, oven, pure steam generation system, purified water and water for injection systems, centrifuge and lyophilizer. 4.4 Quality assurance and Quality control (QA/QC) The consistent production of DNA vaccines to meet therapeutic specification of safety, purity, efficacy and potency depends on good quality assurance and quality control (QA/QC) performed by qualified persons (QP). Quality control of the DNA vaccines is one of the key component of current good manufacturing practices (cGMP) and regulatory guideline of U.S. FDA, WHO, MHRA, ISO 9000 etc. It involves testing procedures employed to check that the DNA vaccines product are uniform from batch-to-batch and raw materials used for its production meet the specification, quality and standard. The quality control testing laboratory consists of the following assays for determining quality of raw materials and product purity, efficacy and safety: High performance liquid chromatography (HPLC) to determine the percentage of RNA, supercoiled and nicked. pH meter test for residual buffer salts and alkaline. Agarose gel electrophoresis (AGE) test for plasmid DNA vaccine purity, determine RNA and genomic DNA presence in the product. Gas chromatography test for the presence of ethanol, determine plasmid size Flame ionization detector (FID) test for the presence of isopropanol in the product. Transfection/Immunofluorescent staining test for potency of plasmid DNA vaccines. Kinetic chromogenic limulus amoebacyte lysate (LAL) test to quantify the presence of endotoxin in the product Sodium dodecylsulfate polyacrylamide gel electrophoresis (SDS-PAGE) test for the quantity of proteins in the product (DNA vaccines). GeneQuant spectrophotometer test to quantify the purity of the DNA vaccines product. Bicinchoninic acid (BCA) assay quantify the amount of proteins present in the bulk product. Mass spectrometer, measuring, weighing, recording and control instruments calibrated regularly. The analytical instruments are validated to ensure performance. The DNA vaccines must meet at least minimum specification, purity, efficacy, safety and quality set by regulatory authority after sterile filling before released (Przybylowski et al., 2007; Prather et al., 2003). 4.4.1 Product testing Prior to the release of the DNA vaccines after blending and formulation, the quality control department must test each batch for purity, identity, efficacy, safety and potency using the analytical assays mentioned above, and if the result does not meet regulatory specifications the batch will not be released (Prazeres and Ferreira, 2004). Table 1 below shows an example of DNA vaccines purity and quality specification. 4.5 Documentation Documentation of all the activities and operations is a key requirement for GMP, regulatory bodies, and helpful for management structure, traceability of every batch history, planning, elimination of errors, effective communication, records keeping and design and layout of the DNA vaccines facility. Regulatory authorities such as FDA, EMEA and WHO require documentary evidence as prove that the DNA vaccines facility will perform consistently in compliance to cGMP. The DNA vaccines project documentation include: standard operational procedures (SOPs), design qualification, installation qualification, facility layout design, specification sheets for each pieces of equipment, performance qualification, quality control records, process flow sheet, site plan, personnel records, licence, commissioning, validation master plan (VMP), packaging, labelling, etc. both on paper and electronically (Signore and Terry, 2008; Sinnott, 2005). 4.6 Utilities Utilities are the support services required for effective design, layout and manufacturing process of DNA vaccines, they include: Potable water, USP purified water used for cleaning in place (CIP) to clean process equipment. Water for injection (WFI) used for media preparation, fermentation media and rinsing of equipment after CIP. Clean steam for sterilisation in place (SIP) to sterilise the process equipment after each batch. Electricity for lightening, instrumentation, analytical instrument, etc. Sterile gases such as filtered sterile air for fermentation process, nitrogen N2 for working cell bank storage, heating, ventilation and air-conditioning (HVAC) system. Refrigeration for the storage of the DNA vaccines product at -20oC. 4.6.1 Heating, Ventilation and Air-Conditioning (HVAC) System Heating, ventilation and air-conditioning (HVAC) system is a component of the production clean rooms design and layout, it plays a vital role in ensuring that the manufactured DNA vaccines product quality, efficacy, safety and purity is not impacted by room temperature, relative humidity (RH), air borne particles, pressure and cross contamination in accordance to standards and classifications of rooms by ISO 14644-1, US Fed. Std. 209, BSS5295, EEC, etc. (Zyl, 2005). The HVAC systems for this manufacturing facility include: High efficiency particulate air (HEPA) filters to control air borne particles, dust and microorganisms of the clean rooms. Desiccant dehumidifiers/refrigerated dehumidifiers are used to monitor and control the temperature and relative humidity (RH) of the rooms in order to comply with raw materials and DNA vaccines product requirement. Airlocks and air handling unit (AHU) are put in place for pressure monitoring, control and maintenance of pressure cascade with the production rooms. 4.6.2 Water and clean steam systems Purified water, water for injection (WFI) and clean steam are essential utilities generated on site and distributed for use in DNA vaccines production, clean-in-place (CIP), sterilisation-in-place (SIP), and media preparation (Robbins, 2010). In order to ensure safety, purity and efficacy of the DNA vaccines the water used for its production is sterile water for injection (WFI). The WFI is produced from purified water by distillation/reverse osmosis to meet the required standard of purity specified by the United State Pharmacopeia (USP) (pH 5.0-7.0, nonpyrogenic and antimicrobial agent). The WFI is stored at elevated temperature (80-95oC) to eliminated microbial growth, and the system constructed with stainless steel to eliminate contamination (Robbins, 2010). The WFI system design is shown in FIG. 4.7 Waste treatment and management The system for treating the waste generate from the DNA vaccines manufacturing facility is an integral part of the design of the facility, layout and good manufacturing practices (GMP). The major waste generate from the production process are genomic DNA of the host cells, RNA, proteins, cell debris, salts, endotoxins and plasmid isoforms (Ferreira et al., 2000). The waste is treated to regulatory standards (BS, ISO, etc.) to avoid harm to health and safety of personnel and environment (HSE), pollution and eliminate cross contamination of the product. The system for treating the waste is illustrated in FIG. below WWWW Incineration Autoclaved Waste Discharge Autoclave 4.7.1 Health, Safety and Environment (HSE) The DNA vaccines production microorganism poses some hazard. The environmental impact assessment (EIA) of the DNA vaccines production system therefore becomes a key part of the design and layout of the manufacturing facility (Prazeres and Ferreira, 2004). However, the environmental impact assessment (EIA) study and the design will require approval from environmental protection agency before the facility is built (Davda, 2004). To ensure that health, safety and environmental regulations are met, the process design and layout is geared towards minimisation of waste generation, safety of product, safety and health of personnel and incorporation of waste treatment process before discharge to the environment. In addition, the personnel will also be provided with personal protective equipment (PPE) such as hand gloves, gowns, goggles, etc. to work with. 4.8 Legislation and regulation The manufacture of DNA vaccines is highly regulated to ensure that it is safe, efficacious and pure for humans, and also its production carried out in accordance to current GMP (Plumb, 2005). Therefore, before the DNA vaccines can be marketed they must be licence from the relevant regulatory bodies such as the Medicines and Healthcare products Regulatory Agency (MHRA) in the United Kingdom, the Food and Drug Administration (FDA) in the United States, the EMEA, WHO and so on (Smith and Dennis, 2001). The manufacturing facility used for the production of the DNA vaccines must be licence too (Plumb, 2005). These licences are obtained if and only if the manufacturing facility design, layout and premises of its manufacture conform and comply to current good manufacturing practices (cGMP) and with regulatory standards, guidelines and specifications stipulated by MHRA, FDA, WHO, EMEA, ISO, etc. Hitherto, the company must also provide detailed documentary evidence about the safety, purity an d efficacy of the DNA vaccines and the consistency of its manufacturing process. Signor and Terry reported that the incorporation of current good manufacturing practices (cGMP) into good design practices (GDP) at the inception of the manufacturing facility will ensure that regulatory conditions are met (Signor and Terry, 2008). The regulatory guidelines specify the requirements for the pharmaceutical manufacturing facility, not the methods to achieving it. The regulatory bodies functions include: safeguard public health, licensing, monitoring DNA vaccines post-marketing, regulating clinical trials and publish quality standards. 5.1 Project timeline This project has a definite start, middle and end, which consist of several activities ranging from the environmental impact assessment and design approval, construction to commissioning executed in a defined order to bring the project to completion. It is the function of the project manager to plan, schedule and control these tasks/activities in a specified sequence and allocate materials, manpower, machinery and money to ensure that the project is completed on time (Gray and Erik, 2008). There are several project management techniques available in the literature, but to estimate the timeline of this project the Gantt chart technique was employed, which a plot of each task against time. Each bar represents a task/activity, length of the bar corresponds to the duration of the task and the position indicate the start and finish times. The timeline for key activities of the project are shown in FIG!!!!!!!!!!!!!! below, the Gantt chart was prepared with reference to (Davda, 2004). The e ntire project is expected to take a year and 4.5 months from the Gantt chart. 6.1 Recommendations 1. Legislations and regulations are subject to changes with emergent of robust technology, therefore the design of the manufacturing facility should be above the current specifications and standards. 2. A well defined and detail engineering drawings and specifications that does not require much interpretation. 3. A good relationship between project design team with relevant regulatory authorities and encouragement of their input will fortify the design of the facility and compliance to cGMP. 4. Ensure that all designs, installations and utilities are validated according to validation master plan (VMP) and are working according to design and specification of regulatory bodies. 5. Compliance with current good manufacturing practices (cGMP) at the inception of the design phase of the facility. 6. The DNA vaccines production facility should be designed and layout to harmonized the various regulations by different bodies such the US FDA, UK MHRA, EU, Japan, ISO, WHO, etc. to boost market for the product. 7. The process parameters such as temperature, pH and pressure must be carefully controlled to assure batch-to-batch identity in final product. 7.1 Conclusion Incorporating current good manufacturing practices (cGMP) from the beginning of the design and layout phase of the DNA vaccines facility, the production processes and to the manufacturing premises will ensure that all regulatory specifications are met.

Working Paper

The term module means that the questionnaire can be used as part of a larger Research experience has shown that the answers to the 24 content questions are influenced by the nationality of the respondents. This is not to say that every respondent of nationality A gives one answer and everyone of a nationality B another, but one can expect systematic differences between the average answers from a sample with nationality A and a comparable sample from nationality B (in statistical terms, an analysis of variance on the answer scores shows a significant country effect).As the relationship is statistical, the samples per country should be of sufficient size. An ideal size for a homogeneous sample is 50 respondents. Sample sizes smaller than 20 should not be used, as outlying answers by single respondents will unduly affect the results. If samples are heterogeneous (composed of unequal sub-samples) these numbers apply to the sub-samples. Next to nationality, answers to the 24 content quest ions will also reflect other characteristics of the respondents, such as their gender, age, level of education, occupation, kind of work and the point in time when they answered the questions.Therefore comparisons of countries should be based on samples of respondents who re matched on all criteria other than nationality that could systematically affect the answers. The content questions attributed to a dimension were selected because in comparisons of matched samples from ten or more countries, the mean country scores on the four questions belonging to the same dimension usually vary together (if one is high, the other is high, or low if it is a reversely formulated question; if one is low, the other is low, etc. ). In statistical terms, the mean country scores are significantly correlated.The mean country scores on questions belonging to different emissions usually do not vary together (are uncorrelated). Therefore, the 24 questions form 6 clusters of 4 questions each. As mentione d above, the dimensions measured by the VS.. Are based on country- level correlations, between mean scores of country samples. For the same two questions, country-level correlations can be very different from individual-level correlations, between the answers by the individuals within the country samples (for a clear explanation see e. G. Klein, Danseuses & Hall, 1994).Individual-level correlations produce dimensions of personality; country-level correlations produce emissions of national culture. For research results about the relationship between personality and culture see Hefted & McCrae (2004). The study of national culture dimensions belongs to anthropology, the study of individual personality belongs to psychology. The first is to the second as studying forests is to studying trees. Forests cannot be described with the same dimensions as trees, nor can they be understood as bunches of trees.What should be added to the animals, organisms and climate factors, together described by the term epitome. In reverse, trees cannot be described with the same dimensions as forests. At best one can ask in what kind of forest this tree would be most likely found, and how well it would do there. A common misunderstanding about dimensions of national culture is that they are personality types. People want to score themselves on a dimension, or worse, try to score someone else. This is called stereotyping, which is not what the dimensions are for.They do not refer to individuals, but to national societies. What a person can do is find out how the values prevailing in his or her national society differ from those in another society. As an individual, a person can express how he or she feels about the values in a particular national society, but that would still be a function of his/her personality and not necessarily show his or her national culture. Because of this, the VS.. 2013 cannot be scored at the individual level. It is not a psychological test.The tendency to as k for individual scoring of the VS.. Is stronger in some national cultures than in others. Especially in very individualist cultures, the request for individual scoring is frequent: the concept of my society (a forest) is weaker that the concept of me myself (a tree). The VS.. Should only be used by researchers who subscribe to the concept of a society differing from other societies. The six dimensions on which the VS.. 2013 is based were found in research across more than 40 countries.In a research project across 20 different organizations within the same two countries, answers to the questions that made up the cross-national dimensions did not correlate in the same way (Hefted, Enquire, Omaha' & Sanders, 1990 and Hefted, Hefted & Moving, 2010: 341-368). So the cross-national dimensions do not apply to organizational (or corporate) cultures. The answers to the VS.. Questions (dealing with values and sentiments) varied less across organizations within a country than across countries .Instead, organizational cultures differed primarily on the basis of perceptions of practices, and the organizations in the study could be compared on six dimensions of perceived practices. While the study of national culture dimensions belongs to anthropology and the study of individual personality belongs to psychology, the study of organizational cultures belongs to sociology. The dimensions of perceived practices in the Hefted et al. 1990) study relate to known distinctions from organizational sociology. A similar concern prohibits the use of the VS.. Dimensions for comparing occupations (Hefted, Hefted & Moving, 2010: 368-369).In some cases, VS.. Dimension scores can be meaningfully computed and compared for the genders (female versus male) and for successive generations (grandparents country or across countries, but in this case we recommend extending the questionnaire with locally relevant items (Hefted, Garibaldi, Melville, Tenure & evokes, 2010). 4. VS.. 2013 scores are not comparable to published scores Some enthusiastic amateurs have used the VS.. With a sample of respondents from one country and tried to draw conclusions comparing the scores they found with those in Hypotheses books (1980, 1991 , 2001 , 2005, 2010).But essential to the use of the VS.. Is that comparisons should be based on matched samples of respondents: people similar on all criteria other than nationality that could systematically affect the answers. All scores in the first two Hefted books were based on carefully matched IBM subsidiary populations. A new sample, to be comparable to these, should be a attach for the original IBM populations on all relevant criteria. Such a match is virtually impossible to make, if only because the IBM studies were done around 1970 and the point in time of the survey is one of the matching characteristics.Hypotheses books since 2001 contain scores for a number of countries not in the original IBM set, based on extensions of the research outside MO M, or in a few cases on informed estimates. Extensions of the research to countries and regions not in the original set have to be based, like any VS.. Application, on matched samples across two or more countries. These should always include one or, if possible, more of the countries from the IBM set, so that the new data can be anchored to the existing framework. Anchoring' means that the scores from the extension research should be shifted by the difference of the old and new scores for the common country (or by the mean difference in the case of more common countries). The main problem of extension research is finding matched samples across new and old countries. Examples of successful extensions are described in Hefted (2001:464-465). The VS.. 2013 has been designed for research purposes. In the classroom it has poor ace validity, as it is based on the logic of national cultures which differs from the logic of individual students. Cultures are not king-size individuals: They are wholes, and their internal logic cannot be understood in the terms used for the personality dynamics of individuals. Echo-logic differs from individual logic† (Hefted, 2001 :17; the term ecological in cross-cultural studies is used for any analysis at the societal level; it does not only refer to the natural environment). To students or audiences without a professional training in anthropology or cross-cultural research the VS.. Is to the proper tool for explaining the essence of the dimensions.In this case trainers should rather develop teaching tools using the tables of differences between societies scoring high and low on each dimension, which are based on significant Hefted & Moving, 2010: Chapters 3-8). The twenty-four content questions allow index scores to be calculated on six dimensions of national value systems as components of national cultures: Power Distance (large vs†¦ Small), Individualism vs†¦ Collectivism, Masculinity vs†¦ Femininity, Uncertaint y Avoidance (strong vs†¦ Weak), Long- vs†¦ Short-Term Orientation, and Indulgence vs†¦ Restraint.All content questions are scored on five-point scales (1-2-3-4-5). Any standard statistical computer program will calculate mean scores on five-point scales, but the calculation can also be done simply by hand. For example, suppose a group of 57 respondents from Country C produces the following scores on question 04 (importance of security of employment): 10 x answer 24 x answer 2 14 x answer 3 5 x answer 4 1 x answer 5 42 20 54 valid answers totaling 125 Three of the 57 respondents gave an invalid answer: either blank (no answer) or multiple (more than one answer).Invalid answers should be excluded from the calculation (treated as missing). The mean score in our case is: 125/54 = 2. 31. Mean scores on five-point scales should preferably be presented in two decimals. More accuracy is unrealistic (survey data are imprecise measures). Power Distance Index (PDP) Power Distanc e is defined as the extent to which the less powerful members of institutions and organizations within a society expect and accept that power is distributed unequally. The index formula is PDP = 35(mom – mom) + 25(mom – mom) + QPS) in which mom is the mean score for question 02, etc.The index normally has a range of about 100 points between very small Power Distance and very large Power Distance countries. C(PDP) is a constant (positive or negative) that depends on the nature of the samples; it does not affect the comparison between countries. It can be chosen by the user to shift her/his PDP scores to values between O and 100. Individualism Index (DIVIDE) Individualism is the opposite of Collectivism. Individualism stands for a society in which the ties between individuals are loose: a person is expected to look after himself or herself and his or her immediate family only.Collectivism stands for a roofs, which continue to protect them throughout their lifetime in exc hange for unquestioning loyalty. DIVIDE = 35(mom – mol) + 35(mom – mom) + C(ICC) in which mol is the mean score for question 01, etc. The index normally has a range of about 100 points between strongly collectivist and strongly individualist countries. C(ICC) is a constant (positive or negative) that depends on the nature of the samples; it does not affect the comparison between countries. It can be chosen by the user to shift his/her DIVIDE scores to values between O and 100.Masculinity Index (MASS) Masculinity is the opposite of Femininity. Masculinity stands for a society in which social gender roles are clearly distinct: men are supposed to be assertive, tough, and focused on material success; women are supposed to be more modest, tender, and concerned with the quality of life. Femininity stands for a society in which social gender roles overlap: both men and women are supposed to be modest, tender, and concerned with the quality of life. MASS = 35(mom – mom ) + 35(mom – mom) + corn) in which mom is the mean score for question 05, etc.The index normally has a range of about 100 points between strongly feminine and strongly masculine countries. C(MFC) is a constant (positive or negative) that depends can be chosen by the user to shift her/his MASS scores to values between O and 100. Uncertainty Avoidance Index (AJAX) Uncertainty Avoidance is defined as the extent to which the members of institutions and organizations within a society feel threatened by uncertain, unknown, ambiguous, or unstructured situations. AU' = 4001118 – mom)+ 25(mom – mom) + qua) in which mom is the mean score for question 18, etc.The index normally has a range of about 100 points between weak Uncertainty Avoidance and strong Uncertainty Avoidance countries. C(AU) is a constant (positive r negative) that depends on the nature of the samples; it does not affect the comparison between countries. It can be chosen by the user to shift his/her I-JAG scores to values between O and 100. Long Term Orientation is the opposite of Short Term Orientation. Long Term Orientation stands for a society which fosters virtues oriented towards future rewards, in particular adaptation, perseverance and thrift.Short Term orientation stands for a society which fosters virtues related to the past and present, in particular respect for tradition, preservation of â€Å"face†, and fulfilling social obligations. LTO = – mom) + 25(mom – mom) + C(IS) n which mom is the mean score for question 13, etc. The index normally has a range of about 100 points between very short term oriented and very long term oriented countries. C(l's) is a constant (positive or negative) that depends on the nature of the samples; it does not affect the comparison between countries. It can be chosen by the user to shift her/his L TO scores to values between O and 100.Indulgence versus Restraint Index (IVR) Indulgence stands for a society which allows rel atively free gratification of some desires and feelings, especially those that have to do with leisure, merrymaking with rinds, spending, consumption and sex. Its opposite pole, Restraint, stands for a society which controls such gratification, and where people feel less able to enjoy their lives. The index formula is IVR = – ml 1) + – mom) + COO in which ml is the mean score for question 11, etc. The index normally has a range of about 100 points between high indulgence and high restraint.C(IR) is a constant (positive or negative) that depends on the nature of the samples; it does not affect the comparison between countries. It can be chosen by the user to shift her/his IVR scores to values between O and 100. As country-level correlations differ from individual-level correlations, answers on questions used to measure a country-level dimension do not necessarily correlate across individuals. A reliability test like Cockroach's alpha should in this case not be based on individual scores but on country mean scores. Obviously this presupposes data from a sufficient number of countries, in practice at least ten.For comparison across fewer countries the reliability of the VS.. At the country level has to be taken for granted; it can indirectly be shown through the validity of the scores in predicting dependent variables. The IBM database (Hefted, 1980) allows to compute Cockroach alphas for the first four dimensions across 40 countries (39 for AAU, 33 for PDP because of missing data). Power Distance Index (3 items): Alpha = . 842 Individualism Index (6 items): Alpha = . 770 Masculinity Index (8 items): Alpha = . 760 Uncertainty Avoidance Index (3 items) Alpha = . 15 The rule of thumb for test reliability is a value over . 700. The new items in the new version were chosen because of their similarity to items in reliable other studies, but the reliability of the new dimension scores cannot be proven a prior'. The VS.. 2013 is copyrighted, but may be fre ely used for academic research projects. Consultants who want to use the VS.. 2013 periodically should pay a license fee based on the number of copies administered per year. The same holds for use by companies in employee surveys. Information on rates is available from the copyright holder ([email  protected] L) 9. History of the VS.. 2013 The original questions from the 1966-1973 Hermes (MOM) attitude survey questionnaires used for the international comparison of work-related values were listed in Hefted (1980, Appendix 1). Appendix 4 of the same book presented the iris Values Survey Module for future cross-cultural studies. It contained 27 content questions and 6 demographic questions. This VS.. 80 was a selection from the IBM questionnaires, with a few questions added from other sources about issues missing in the IBM list and Judged by the author to be of potential importance.In the 1984 abridged paperback edition of Hefted (1980) the original IBM questions were not included, but the VS.. 80 was. A weakness of the VS.. 80 was its dependence on the more or less accidental set of questions used in the IBM surveys. The IBM survey questionnaire had not really been imposed for the purpose of reflecting international differences in value patterns. However, the IBM questions could only be replaced by other questions after these had been validated across countries; and to be validated, they had to be used in a large number of countries first.Therefore in 1981 Hefted through the newly- founded Institute for Research on Intercultural Cooperation (IIRC) issued an experimental extended version of the VS.. (VS.. 81). On the basis of an analysis of its first results, a new version was issued in 1982, the VS.. 82. This was widely used for the next twelve years. 3 of the questions were needed to compute scores on the four dimensions identified by Hefted. The other questions were included for experimental use. Some questions in the VS.. 82 were only applicable to employe d respondents.Thus the instrument could not be used for entrepreneurs, students, and respondents without a paid Job. The number of replications using the VS.. 82 in Iris's files increased, but, unfortunately, it turned out that the samples from different researchers were insufficiently matched for producing a reliable new VS†¦ This changed when Michael Hope published his Ph. D. Hess on a survey study of elites (Syllabus Seminar Alumni) from 19 countries, using among other instruments the VS.. 82 (Hope, 1990). Eighteen of these countries were part of the IBM set, but besides USA all of them were from Europe.Hope's data base was therefore extended by adding results from replications in six countries in Africa, Asia and Latin America that could be considered somewhat matched with the Hope set. In the meantime, the research of Michael Harris Bond from Hong Kong, using the Chinese Value Survey (Chinese Culture Connection, 1987), had led to the identification f a fifth dimension: Lon g-Term versus Short-Term Orientation (Hefted & Bond, 1988; Hefted, 2001: Chapter 7). In the new version of the VS.. Published in 1994 (the VS.. 94), this dimension appeared for the first time together with the other four.The questionnaire was also adapted to respondents without a paid Job. Accumulated experience with the use of the VS.. 94 in the next 14 years led to the publication of an updated VS.. 08. In the meantime, many new sources of cross- cultural survey information became available. One was an unpublished Master's Thesis (Van Bug, 2006) reporting on the Internet administration of the VS.. 94 among active members of the student association EASIES in 41 countries, collecting some 2,200 valid answers, a response rate of 24%.We also looked for questions correlated with the IBM dimensions in the newly available sources, including the huge World Values Survey database freely accessible on Internet (Ingather and associates, 1998, 2004, 2007). In 2007, Michael Moving published a book integrating all available old and new databases, and we invited him to Join the VS.. Team. Moving (2007) proposed three new dimensions: Exclusion versus Universalism, Indulgence versus Restraint, and Monumentality versus Flexibility (flexibility plus nullity).From these, Exclusion versus Universalism across 41 countries was strongly correlated with Power Distance and Collectivism (both r = . 74), so we did not treat it as a new dimension. Indulgence versus Restraint was uncorrelated with any of the five dimensions in the VS.. 94 and it added new insights into national cultural differences, so we accepted it as a new and sixth dimension. Monumentality versus Flexibility was significantly correlated with Short Term Orientation (r = . 68 across 16 overlapping countries) and less strongly with Power